HO-PEG14-OH is widely used in the field of bioconjugation and drug delivery due to its hydrophilic and biocompatible properties. It serves as a linker or spacer in the development of PEGylated drugs, enhancing solubility and prolonging circulation time in the bloodstream. This chemical is also utilized in the modification of proteins, peptides, and antibodies to improve their stability and reduce immunogenicity. Additionally, it finds applications in the synthesis of hydrogels and other biomaterials, where it contributes to controlled drug release and tissue engineering. Its role in nanotechnology is significant, as it aids in the surface modification of nanoparticles for targeted delivery systems.