NS6180 is primarily utilized in pharmacological research due to its role as a potent and selective activator of KCa3.1 potassium channels. These channels are significant in regulating various cellular processes, particularly in immune cells, endothelial cells, and smooth muscle cells. In research settings, NS6180 is employed to study the physiological and pathological roles of KCa3.1 channels, such as their involvement in inflammatory responses, vascular tone regulation, and cell proliferation. Its application extends to exploring potential therapeutic strategies for conditions like asthma, atherosclerosis, and certain cancers, where modulation of KCa3.1 activity could offer clinical benefits. Additionally, NS6180 serves as a valuable tool in electrophysiological studies to understand channel behavior and drug-channel interactions.