(S,R,S)-AHPC-O-Ph-PEG1-NH-Boc
97%
Reagent
Code: #106008
CAS Number
2409007-40-3
blur_circular Chemical Specifications
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Molecular Information
Weight
723.88 g/mol
Formula
C₃₇H₄₉N₅O₈S
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Storage & Handling
Storage
2-8°C, dry, sealed
description Product Description
Used in the field of targeted protein degradation, this compound is a key component in the development of PROTACs (Proteolysis Targeting Chimeras). It facilitates the selective degradation of specific proteins by linking a target protein to an E3 ubiquitin ligase, leading to its ubiquitination and subsequent proteasomal degradation. This mechanism is particularly valuable in drug discovery, especially for targeting undruggable proteins in diseases like cancer, neurodegenerative disorders, and autoimmune conditions. Its structure, featuring a Boc-protected amine and PEG linker, ensures stability and efficient cellular uptake, making it a versatile tool in chemical biology and therapeutic research.
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(S,R,S)-AHPC-O-Ph-PEG1-NH-Boc
Used in the field of targeted protein degradation, this compound is a key component in the development of PROTACs (Proteolysis Targeting Chimeras). It facilitates the selective degradation of specific proteins by linking a target protein to an E3 ubiquitin ligase, leading to its ubiquitination and subsequent proteasomal degradation. This mechanism is particularly valuable in drug discovery, especially for targeting undruggable proteins in diseases like cancer, neurodegenerative disorders, and autoimmune conditions. Its structure, featuring a Boc-protected amine and PEG linker, ensures stability and efficient cellular uptake, making it a versatile tool in chemical biology and therapeutic research.
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