Homo-PROTAC pVHL30 degrader 1 is a specialized proteolysis-targeting chimera (homo-PROTAC) used in targeted protein degradation research. It features a homodimeric structure with pVHL30 ligands that recruit the von Hippel-Lindau (VHL) E3 ubiquitin ligase, enabling selective degradation of proteins of interest via the ubiquitin-proteasome system. This compound is essential for studying disease-related proteins, especially in cancer research, where it aids in elucidating protein functions, validating therapeutic targets, and investigating cellular pathways. Its applications extend to chemical biology and drug discovery, serving as a precise tool to modulate protein interactions and levels for developing innovative treatments.