VH032-PEG5-C6-Cl, known as HaloPROTAC 2, is primarily used in targeted protein degradation studies. It functions as a proteolysis-targeting chimera (PROTAC) to selectively degrade proteins of interest. This compound is particularly valuable in research involving HaloTag fusion proteins, where it binds to the HaloTag and recruits an E3 ubiquitin ligase, leading to ubiquitination and subsequent degradation of the target protein by the proteasome. Its applications include studying protein function, validating drug targets, and exploring disease mechanisms in cellular and biochemical assays. HaloPROTAC 2 is a versatile tool in chemical biology and drug discovery for modulating protein levels with high specificity.