2-(2,6-Dioxopiperidin-3-yl)-5-methylisoindoline-1,3-dione
98%
Reagent
Code: #128882
CAS Number
40313-92-6
blur_circular Chemical Specifications
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Molecular Information
Weight
272.26 g/mol
Formula
C₁₄H₁₂N₂O₄
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Registry Numbers
MDL Number
MFCD30290642
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Storage & Handling
Storage
2-8°C
description Product Description
Widely used in pharmaceutical research, this compound serves as a key intermediate in the synthesis of immunomodulatory drugs. It is particularly valuable in the development of targeted protein degraders, such as cereblon E3 ligase modulators, which are used in cancer therapies. Its structure enables selective binding to cereblon, facilitating the degradation of disease-causing proteins. Due to this mechanism, it plays a critical role in the design of treatments for hematological malignancies, including multiple myeloma and myelodysplastic syndromes. It is also explored for anti-inflammatory and anti-angiogenic applications in preclinical studies.
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