5-(Bromomethyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
98%
Reagent
Code: #130189
CAS Number
1312023-72-5
blur_circular Chemical Specifications
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Molecular Information
Weight
351.15 g/mol
Formula
C₁₄H₁₁BrN₂O₄
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Registry Numbers
MDL Number
MFCD34601661
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Physical Properties
Boiling Point
583.1±50.0 °C(Predicted)
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Storage & Handling
Density
1.745±0.06 g/cm3(Predicted)
Storage
2-8°C, Sealed, Inert Gas
description Product Description
Used primarily in pharmaceutical research as a key intermediate in the synthesis of targeted protein degraders, particularly cereblon E3 ligase modulators. Its bromomethyl functional group allows for efficient conjugation to other molecules, enabling the development of PROTACs (proteolysis-targeting chimeras) that direct specific proteins for degradation. This compound is valuable in oncology and immunology drug discovery due to its role in enhancing selectivity and potency of therapeutic agents. It is also employed in the preparation of analogs for structure-activity relationship studies.
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