3-(7-Fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione
97%
Reagent
Code: #130550
CAS Number
2287267-33-6
blur_circular Chemical Specifications
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Molecular Information
Weight
262.24 g/mol
Formula
C₁₃H₁₁FN₂O₃
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Registry Numbers
MDL Number
MFCD31746002
thermostat
Physical Properties
Boiling Point
545.3±50.0 °C(Predicted)
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Storage & Handling
Storage
Room temperature, seal, inert gas
description Product Description
Used in pharmaceutical research as a key intermediate for synthesizing targeted protein degraders, particularly cereblon E3 ligase modulators. It plays a critical role in the development of immunomodulatory drugs that promote the degradation of disease-causing proteins in conditions like multiple myeloma and other hematological cancers. Its structure enables selective binding to cereblon, enhancing the ubiquitination and subsequent degradation of specific cellular proteins involved in tumor growth and inflammation. Due to its potent biological activity, it is primarily used in preclinical studies and drug discovery programs focused on oncology and immune-mediated diseases.
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