2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxylic acid

97%

Reagent Code: #130707
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CAS Number 2171780-01-9

blur_circular Chemical Specifications

scatter_plot Molecular Information
Weight 288.26 g/mol
Formula C₁₄H₁₂N₂O₅
badge Registry Numbers
MDL Number MFCD31735773
thermostat Physical Properties
Boiling Point 667.4±55.0 °C(Predicted)
inventory_2 Storage & Handling
Density 1.535±0.06 g/cm3(Predicted)
Storage Room temperature, light-proof, inert gas

description Product Description

Used primarily in pharmaceutical research as a key intermediate in the synthesis of immunomodulatory drugs, particularly analogs of thalidomide such as lenalidomide. It plays a critical role in targeted protein degradation therapies, including the development of cereblon E3 ligase modulators. These compounds are investigated for their anticancer, anti-inflammatory, and antiproliferative properties, especially in hematological malignancies like multiple myeloma and myelodysplastic syndromes. Its structure enables selective binding to cereblon, facilitating the degradation of disease-causing proteins. Widely utilized in medicinal chemistry for designing PROTACs (proteolysis-targeting chimeras) and optimizing drug candidates with improved efficacy and safety profiles.

shopping_cart Available Sizes & Pricing

Size Availability Unit Price Quantity
inventory 100mg
10-20 days ฿5,050.00
inventory 250mg
10-20 days ฿9,590.00
inventory 1g
10-20 days ฿28,740.00

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