2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindoline-5-carboxylic acid
97%
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Used primarily in pharmaceutical research as a key intermediate in the synthesis of immunomodulatory drugs, particularly analogs of thalidomide such as lenalidomide. It plays a critical role in targeted protein degradation therapies, including the development of cereblon E3 ligase modulators. These compounds are investigated for their anticancer, anti-inflammatory, and antiproliferative properties, especially in hematological malignancies like multiple myeloma and myelodysplastic syndromes. Its structure enables selective binding to cereblon, facilitating the degradation of disease-causing proteins. Widely utilized in medicinal chemistry for designing PROTACs (proteolysis-targeting chimeras) and optimizing drug candidates with improved efficacy and safety profiles.
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