1-(2,6-Dioxopiperidin-3-yl)-5-oxopyrrolidine-3-carboxylic acid
80%
Reagent
Code: #131620
CAS Number
1498191-33-5
blur_circular Chemical Specifications
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Molecular Information
Weight
240.21 g/mol
Formula
C₁₀H₁₂N₂O₅
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Registry Numbers
MDL Number
MFCD23167038
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Physical Properties
Boiling Point
613.6±55.0 °C(Predicted)
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Storage & Handling
Density
1.523±0.06 g/cm3(Predicted)
Storage
2-8°C, Sealed, Inert Gas
description Product Description
Used primarily in pharmaceutical research as a key intermediate in the synthesis of immunomodulatory drugs, particularly those related to thalidomide analogs. It plays a critical role in the development of targeted protein degraders such as PROTACs, where it serves as a ligand for cereblon (CRBN), a component of the E3 ubiquitin ligase complex. By recruiting cereblon, this compound enables the selective degradation of disease-related proteins, making it valuable in oncology and inflammatory disease research. Its structure allows for chemical modifications that enhance binding affinity, selectivity, and pharmacokinetic properties in drug candidates.
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