3-(1-Oxo-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoindolin-2-yl)piperidine-2,6-dione

98%

Reagent Code: #132370
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CAS Number 2193080-10-1

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Weight 370.21 g/mol
Formula C₁₉H₂₃BN₂O₅
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Used in pharmaceutical research as a key intermediate in the synthesis of targeted protein degraders, particularly cereblon (CRBN)-based PROTACs (proteolysis-targeting chimeras). Its structure enables conjugation to E3 ubiquitin ligase ligands, facilitating the degradation of disease-causing proteins. The boronic ester group allows for Suzuki-Miyaura cross-coupling, making it valuable in modular drug design for oncology and inflammatory diseases. Commonly employed in medicinal chemistry for structure-activity relationship (SAR) studies due to its stable isoindoline and piperidine-2,6-dione core.

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inventory 1g
10-20 days ฿28,500.00

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