3-(5-bromo-4-chloro-1-oxoisoindolin-2-yl)piperidine-2,6-dione
97%
Reagent
Code: #140679
CAS Number
2474671-24-2
blur_circular Chemical Specifications
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Molecular Information
Weight
357.59 g/mol
Formula
C₁₃H₁₀BrClN₂O₃
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Storage & Handling
Storage
2-8°C, sealed, dry
description Product Description
Used primarily as a key intermediate in the synthesis of targeted protein degraders, particularly cereblon E3 ligase modulators. It plays a critical role in the development of immunomodulatory drugs that selectively tag disease-causing proteins for degradation. Its structure enables high binding affinity to cereblon, making it valuable in oncology research, especially in therapies for hematological cancers such as multiple myeloma and myelodysplastic syndromes. Also utilized in the design of PROTACs (proteolysis-targeting chimeras) due to its ability to recruit E3 ubiquitin ligase complexes.
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