3-(6-Bromo-5-methoxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione

98%

Reagent Code: #140682
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CAS Number 2438237-48-8

blur_circular Chemical Specifications

scatter_plot Molecular Information
Weight 353.17 g/mol
Formula C₁₄H₁₃BrN₂O₄
inventory_2 Storage & Handling
Storage 2-8°C

description Product Description

Used primarily in pharmaceutical research as a key intermediate in the synthesis of targeted protein degraders, particularly cereblon (CRBN)-based E3 ligase modulators. Its structural features enable selective binding to CRBN, facilitating the ubiquitination and subsequent degradation of disease-related proteins. This makes it valuable in developing treatments for cancers, especially hematological malignancies like multiple myeloma and myelodysplastic syndromes. It is also explored in the design of PROTACs (proteolysis-targeting chimeras) for degrading otherwise undruggable targets. Due to its bromo and methoxy functional groups, it serves as a versatile building block for further chemical modifications in drug discovery programs.

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Size Availability Unit Price Quantity
inventory 25mg
10-20 days ฿11,300.00
inventory 100mg
10-20 days ฿33,080.00
inventory 250mg
10-20 days ฿66,160.00
inventory 1g
10-20 days ฿198,500.00
inventory bulk
10-20 days ฿0.00

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