3-(6-Bromo-5-methoxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione
98%
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Used primarily in pharmaceutical research as a key intermediate in the synthesis of targeted protein degraders, particularly cereblon (CRBN)-based E3 ligase modulators. Its structural features enable selective binding to CRBN, facilitating the ubiquitination and subsequent degradation of disease-related proteins. This makes it valuable in developing treatments for cancers, especially hematological malignancies like multiple myeloma and myelodysplastic syndromes. It is also explored in the design of PROTACs (proteolysis-targeting chimeras) for degrading otherwise undruggable targets. Due to its bromo and methoxy functional groups, it serves as a versatile building block for further chemical modifications in drug discovery programs.
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