3-(5-bromo-6-methoxy-1-oxo-isoindolin-2-yl)piperidine-2,6-dione
99%
Reagent
Code: #140686
CAS Number
2438240-01-6
blur_circular Chemical Specifications
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Molecular Information
Weight
353.17 g/mol
Formula
C₁₄H₁₃BrN₂O₄
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Storage & Handling
Storage
2-8°C, sealed, dry
description Product Description
Used in pharmaceutical research as a key intermediate for synthesizing targeted protein degraders, particularly cereblon (CRBN)-based PROTACs (proteolysis-targeting chimeras). Its structure enables selective binding to cereblon E3 ubiquitin ligase, facilitating the degradation of disease-related proteins. This compound is valuable in developing treatments for cancers and other conditions involving dysregulated protein expression. It is also employed in structure-activity relationship (SAR) studies to optimize potency, selectivity, and pharmacokinetic properties of novel therapeutics.
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