5-Bromo-2-(2,6-Dioxopiperidin-3-Yl)-4-Fluoroisoindoline-1,3-Dione

98%

Reagent Code: #153977
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CAS Number 2740657-28-5

blur_circular Chemical Specifications

scatter_plot Molecular Information
Weight 355.12 g/mol
Formula C₁₃H₈BrFN₂O₄
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Storage Room temperature

description Product Description

Used primarily in pharmaceutical research as a key intermediate in the synthesis of targeted protein degraders, especially cereblon E3 ligase modulators. Its structure enables selective binding to cereblon, making it valuable in developing PROTACs (proteolysis-targeting chimeras) for cancer therapy and inflammatory diseases. The bromo and fluoro substituents allow further functionalization via cross-coupling reactions, facilitating the creation of diverse compound libraries for drug discovery. Also employed in studies involving molecular glues and ubiquitin-proteasome system modulation due to its ability to induce degradation of specific disease-related proteins.

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Size Availability Unit Price Quantity
inventory 100mg
10-20 days ฿15,000.00

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