4-chloro-2-(1-methyl-2,6-dioxopiperidin-3-yl)isoindole-1,3-dione

98%

Reagent Code: #157559

blur_circular Chemical Specifications

scatter_plot Molecular Information
Weight 306.04 g/mol
Formula C₁₄H₁₁O₄ClN₂
inventory_2 Storage & Handling
Storage 2-8 °C, sealed, dry

description Product Description

Used primarily as a key intermediate in the synthesis of immunomodulatory drugs, particularly in the development of cereblon E3 ligase modulators. It plays a critical role in targeted protein degradation therapies, including the production of compounds like lenalidomide derivatives. Its structure enables selective binding to cereblon, making it valuable in creating molecules that can redirect the ubiquitin-proteasome system for degradation of disease-related proteins. Widely applied in pharmaceutical research for cancer treatment, especially in hematological malignancies such as multiple myeloma and myelodysplastic syndromes. Also utilized in the design of PROTACs (proteolysis-targeting chimeras) due to its ability to engage E3 ligase machinery effectively.

shopping_cart Available Sizes & Pricing

Size Availability Unit Price Quantity
inventory 100mg
10-20 days ฿5,760.00
inventory 250mg
10-20 days ฿11,520.00
inventory bulk
10-20 days ฿0.00

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