Ac-WEHD-AFC
98%
Reagent
Code: #107488
CAS Number
210344-99-3
blur_circular Chemical Specifications
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Molecular Information
Weight
838.8 g/mol
Formula
C₃₈H₃₇F₃N₈O₁₁
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Storage & Handling
Storage
-20°C, airtight, dry
description Product Description
This compound is primarily used in biochemical research as a fluorogenic substrate for caspase-1 and other related caspases. It is instrumental in studying apoptosis and inflammation processes, as caspase-1 plays a critical role in these pathways. Researchers utilize it to measure caspase activity in vitro, enabling the assessment of enzyme kinetics and inhibitor screening. The AFC (7-amino-4-trifluoromethylcoumarin) moiety is cleaved upon caspase activation, releasing a fluorescent signal that can be quantified to determine enzymatic activity. This makes it a valuable tool in drug discovery and the study of cellular mechanisms underlying diseases like cancer and autoimmune disorders.
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