1-Boc-4,4-dimethyl-L-proline Methyl Ester
95%
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description Product Description
This compound, 1-Boc-4,4-dimethyl-L-proline methyl ester, is primarily used in organic synthesis, particularly in peptide chemistry. It serves as a dually protected form of 4,4-dimethyl-L-proline, where the Boc (tert-butoxycarbonyl) group safeguards the amine functionality and the methyl ester protects the carboxylic acid during reactions. This allows for selective modification of other parts of the molecule without affecting the amine or carboxylic groups. The 4,4-dimethyl substitution at the pyrrolidine ring provides steric bulk, which can constrain peptide conformations and enhance stability in peptidomimetics. It is commonly employed in the synthesis of complex peptides and peptidomimetics, which are crucial in drug discovery and development. Additionally, its stability and ease of deprotection make it a valuable intermediate in the preparation of biologically active compounds, including pharmaceuticals targeting various diseases.
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