Used in biomedical research to quantify AFG3L2 protein levels in cell lysates, tissue extracts, and biological fluids. Enables studies on mitochondrial protein quality control, neurodegenerative diseases such as spinocerebellar ataxia, and mitochondrial dysfunction. Supports investigation into disease mechanisms, biomarker validation, and evaluation of therapeutic interventions targeting mitochondrial proteostasis. Widely applied in neuroscience, cell biology, and clinical research settings.