Used in research settings to quantify levels of Cartilage Oligomeric Matrix Protein (COMP) in biological samples such as serum, plasma, or tissue extracts. This assay helps in studying cartilage turnover and joint health, making it valuable in osteoarthritis and rheumatoid arthritis research. It enables monitoring of disease progression and the effects of therapeutic interventions on cartilage degradation. Commonly applied in preclinical studies, clinical research, and biomarker validation where non-invasive assessment of skeletal tissue metabolism is required.