Used in biomedical research to quantify YKL-40 levels in biological samples such as serum, plasma, and cell culture supernatants. Helps in studying inflammatory diseases including rheumatoid arthritis, asthma, and inflammatory bowel disease. Supports cancer research by measuring YKL-40 as a biomarker for tumor progression, particularly in glioblastoma, breast cancer, and melanoma. Applied in neurological studies to assess neuroinflammation and neurodegeneration, with relevance to Alzheimer's and multiple sclerosis. Enables researchers to evaluate disease severity and monitor response to therapy in clinical and preclinical settings.