JWH 251 3-methylphenyl isomer is primarily used in research settings to study its interaction with cannabinoid receptors, particularly CB1 and CB2. Its application is focused on understanding the pharmacological effects of synthetic cannabinoids on the endocannabinoid system. Researchers utilize this compound to explore its binding affinity, receptor activation, and potential behavioral or physiological impacts. This helps in gaining insights into the development of therapeutic agents targeting cannabinoid receptors for conditions like pain, inflammation, and neurological disorders. Additionally, it serves as a reference compound in forensic and toxicology studies to identify and analyze synthetic cannabinoids in legal and regulatory contexts.