Pure-Spermidine™ (98%)

Spermidine is a naturally occurring polyamine compound found in a variety of food sources, including cheese, soy products, and grains. There are various studies on its skin benefits:

Anti-aging: Spermidine has been found to have anti-aging properties when applied topically. It may help increase skin elasticity and reduce the appearance of wrinkles.

Wound healing: Spermidine has been found to promote wound healing by increasing angiogenesis and new skin cell growth when applied topically.

Moisturizing: Spermidine has been found to have moisturizing properties when applied topically. It may help retain skin moisture and improve skin hydration.

Here are the key topical benefits of spermidine, with research citations shown as text references:

• Induces autophagy for cellular homeostasis and anti-aging.
  Spermidine inhibits EP300 acetyltransferase, activating macroautophagy to clear damaged proteins and organelles, thereby reducing oxidative stress and supporting skin cell longevity [1].
  
  

• Accelerates skin wound healing.
  Topical application of spermidine mixed in petrolatum significantly speeds wound closure in mice by activating the urokinase-type plasminogen activator (uPA)/uPAR pathway and promoting keratinocyte proliferation and migration [2].
  
  

• Enhances skin barrier integrity and hydration.
  Spermidine—secreted by certain Streptococcus species in the skin microbiome—recovers dermal structure and strengthens barrier function, leading to improved hydration, reduced transepidermal water loss, and greater resilience against external irritants [3].
  
  

• Upregulates collagen and lipid synthesis.
  By increasing expression of genes involved in collagen (COL1A1, COL3A1) and lipid production, spermidine improves skin firmness, elasticity, and smoothness, and reduces excessive desquamation in aged skin models [3].
  
  
  

References

1. Minois N. Molecular Basis of the “Anti-Aging” Effect of Spermidine and Other Natural Polyamines—A Mini-Review. Gerontology. 2014;60(4):319-326. doi:10.1159/000356748
   
   

2. Ito D, Ito H, Ideta T, et al. Systemic and topical administration of spermidine accelerates skin wound healing through activation of the uPA/uPAR pathway. Cell Commun Signal. 2021;19(1):17. doi:10.1186/s12964-021-00717-y
   
   

3. Kim G, Kim M, Kim M, et al. Spermidine-induced recovery of human dermal structure and barrier function by skin microbiome. Commun Biol. 2021;4(1):231. doi:10.1038/s42003-020-01619-4 
   
   
   

Usage: Can be used in all types of skin care products.

Mixing method: Mix in the formula in the last step after getting the cream or gel texture by blending to disperse in the formula and avoid heat.

Usage rate: 0.1%

Product characteristics: Light-colored powder (or liquid at temperatures above 29C)

Solubility: Soluble in water (max. 0.5%).

Storage: For long-term storage, keep in the refrigerator, avoid light and heat, seal the lid tightly, shelf life is at least 2 years.

INCI Name : Spermidine