Pure-CAPE™ (95%, Caffeic acid phenethyl ester)
Cosmetics
Code: 35280
Anti-inflammatory and Antioxidan, UV Protection and Anti-photoaging, extracted from Propolis
Caffeic Acid Phenethyl Ester (CAPE), a natural compound derived from propolis, exhibits a range of pharmacological properties beneficial for topical application
1. Anti-inflammatory and Antioxidant Properties: CAPE has been recognized for its anti-inflammatory and antioxidant effects. A study published in the International Journal of Oral Science demonstrated that CAPE protects against oxidative stress and dampens inflammation via the heme oxygenase 1 (HO1) pathway. This was observed in preclinical models where CAPE protected against ligature-induced periodontitis and systemic bone loss by cortisone, supporting bone defect healing. The study concluded that CAPE exerted its antioxidative effects through the Nrf2-mediated HO1 pathway and its anti-inflammatory effects through NF-κB, highlighting its potential in periodontal disease treatment[3].
2. UV Protection and Anti-photoaging: Another study, published in the International Journal of Molecular Sciences, investigated the effects of CAPE on UV-induced MMP-1 expression in human skin. Chronic sun exposure, which can lead to distinct histone acetylation changes in human skin, is associated with the aging process. CAPE was found to inhibit UV-induced MMP-1 expression by targeting histone acetyltransferases, suggesting its role in preventing the degradation of collagen and the extracellular matrix in the skin. This indicates CAPE's potential as a protective agent against UV-induced skin damage and photoaging[5].
These studies underscore CAPE's promising topical benefits, particularly its anti-inflammatory, antioxidant, and anti-photoaging properties, making it a valuable component in skincare formulations aimed at protecting and repairing the skin.
Citations:
[1] https://onlinelibrary.wiley.com/doi/10.1002/ptr.7707
[2] https://www.sciencedirect.com/science/article/pii/S1756464623002372
[3] https://www.nature.com/articles/s41368-018-0039-5
[4] https://www.sciencedirect.com/topics/medicine-and-dentistry/caffeic-acid-phenethyl-ester
[5] https://www.mdpi.com/1422-0067/20/12/3055
Usage: For all kinds of cosmetics
Mixing method: Mix in ethanol
Usage rate: 0.05-0.1%
Product characteristics: light colored powder
Solubility: Limited solubility in ethanol (about 1%)
Storage: For long-term storage Store in the refrigerator. Temperature between 4 °C -8 °C At least 24 months old
INCI Name : Caffeic Acid (Phenethyl Ester)
- Room (25-40C)
- 24 Months from manufacturing or testing date.
- 0.10% - 0.50%
- 0.50%
- Please follow instruction under product info carefully.
- Avoid heat above 40C
- 4.00 - 7.00
- Soluble in glycols, Soluble in Ethoxydiglycol, Soluble in Ethanol, Soluble in DMSO (Dimethyl Sulfoxide)
- Cream, Lotion, Serum, Active Ingredient
- -
| Test Name | Specification |
|---|---|
| Appearance | Brown yellow granular powder |
| Odor | Characteristic |
| Taste | Characteristic |
| Bulk Density | 20-60g/100mL |
| Particle size | NLT 90% through 80 mesh |
| Assay | ≥98.0% |
| Identification | Correspond to the RS |
| Loss on drying | <5.0% |
| Ash | <5.0% |
| Total Heavy Metals | <10 ppm |
| Lead (Pb) | <3.0ppm |
| Arsenic (As) | <2.0 ppm |
| Cadmium (Cd) | <1.0 ppm |
| Mercury (Hg) | <0.1 ppm |
| Aerobic bacterial count | <10,000 cfu/g |
| Total Yeast & Mold | <1,000 cfu/g |
| Escherichia coli | Negative |
| Salmonella | Negative |
| Staphlococcus | Negative |
search
hourglass_emptyLoading product examples...
Cart
No products
Subtotal:
0.00
Total
0.00
THB
Loading Researcher Network details...