Used as a key reagent in organic synthesis, particularly for introducing the 4-methylpyridine-2-sulfonyl group to amines and alcohols, enabling protection or modification of functional groups in pharmaceutical intermediates. It is valuable in the development of sulfonamide-based drugs due to its ability to form stable sulfonate esters and sulfonamides. Its pyridine ring enhances solubility and coordination properties, making it useful in ligand design for catalysis. Also employed in the preparation of bioactive molecules and agrochemicals where selective sulfonylation is required.