Used as a key intermediate in the synthesis of pharmaceuticals, particularly in the development of kinase inhibitors for cancer treatment. It serves as a building block in agrochemicals, contributing to the creation of herbicides and insecticides due to its reactive chloro and ester functionalities. The presence of the trifluoromethyl group enhances lipophilicity and metabolic stability, making it valuable in optimizing drug candidates. Commonly employed in cross-coupling reactions to introduce the pyrimidine core into larger bioactive molecules.