4,6-Bis(3,5-dichlorophenyl)-2-methylpyrimidine serves as a key intermediate in the synthesis of strobilurin fungicides. These fungicides exhibit high efficacy in preventing and controlling fungal diseases in various economic crops, including rice, wheat, potatoes, and vegetables. They are particularly effective against rust, black spot, and leaf blight. Strobilurins inhibit fungal respiration at the mitochondrial level, disrupting energy production and ultimately halting growth and causing death of the fungi. Owing to their specificity to fungi and low toxicity to humans and the environment, strobilurins are widely employed in agriculture, especially in formulations combined with other fungicides to mitigate resistance development.