Used in immunological research to study T-cell regulation and immune checkpoint pathways. Facilitates the development of therapeutic antibodies targeting the TIGIT pathway, which plays a key role in suppressing T-cell activation. Commonly employed in binding assays, protein-protein interaction studies, and structural analysis due to its functional activity and His-tag for easy detection and purification. Valuable in preclinical studies involving non-human primate models for cancer immunotherapy and autoimmune diseases.