Used in immunological research to study the role of BTN3A1 in γδ T cell activation, particularly in tumor immunity and infectious disease responses. The His tag enables efficient purification and detection, making it valuable in protein-protein interaction studies and high-throughput screening assays. Commonly applied in the development of immunotherapies targeting the BTN3A1 pathway to enhance anti-cancer immune responses. Also utilized as an antigen in antibody production and diagnostic assays for immune monitoring.