Used in immunological research to study T cell activation and co-stimulatory signaling pathways. Plays a role in developing immunotherapies, particularly in cancer and autoimmune diseases. The His Tag allows for easy purification and detection in experimental settings. Commonly used in binding assays to evaluate interactions with ligands or therapeutic antibodies targeting the 4-1BB pathway. Supports the development and characterization of checkpoint inhibitors and agonist antibodies in preclinical studies.