Used in research settings for studying cell signaling pathways related to semaphorin receptors, particularly in cancer biology and neuronal development. Facilitates the investigation of receptor-ligand interactions due to its functional aldehyde tag (CHO), enabling site-specific conjugation for labeling or immobilization. Employed in protein-protein interaction assays, structural studies, and development of targeted therapeutics. Its recombinant form allows consistent and specific targeting of plexin-mediated pathways in human disease models.