Used in research and development of biopharmaceuticals targeting tumor necrosis factor alpha (TNF-α), particularly in the study of inflammatory and autoimmune diseases such as rheumatoid arthritis, Crohn's disease, and psoriasis. Acts as a modified protein construct to investigate inhibition mechanisms of TNF-α activity, aiding in the design of therapeutic antibodies or biosimilars. Employed in binding assays, structural analysis, and drug screening due to its specific aldehyde tag (CHO-K) that enables site-specific conjugation or immobilization. Valuable tool in biochemical and cellular studies for understanding TNF-α signaling pathways and evaluating potential anti-inflammatory compounds.