VTP-27999 TFA is a selective renin inhibitor primarily utilized in research settings, particularly in the fields of medicinal chemistry and pharmacology. It is employed as a tool compound to study the role of renin and the renin-angiotensin system in various disease models, such as chronic kidney disease and hypertension. Researchers use it to investigate potential therapeutic effects on blood pressure regulation and fluid balance. Its application extends to preclinical studies, where it helps in understanding drug mechanisms and optimizing lead compounds for further development. Additionally, it may be used in biochemical assays to evaluate inhibition of specific pathways, contributing to the discovery of novel drug candidates for cardiovascular and metabolic disorders.