Diethylstilbestrol has been historically used in medical applications, primarily as a synthetic estrogen to treat various conditions. It was commonly prescribed to prevent miscarriages and manage menopausal symptoms, though its use for these purposes has been largely discontinued due to associated health risks. In veterinary medicine, it has been utilized to promote growth in livestock and manage reproductive issues in animals. Additionally, it has been employed in certain hormonal therapies and research studies to understand estrogen-related mechanisms. However, its application is now heavily restricted due to its carcinogenic potential and adverse effects on human health.