GBR 12935 dihydrochloride is primarily used in scientific research to study the dopamine transporter (DAT). It acts as a selective dopamine reuptake inhibitor, making it a valuable tool for understanding dopamine-related neurological processes. Researchers utilize it to investigate the mechanisms of dopamine uptake in the brain, which is crucial for studying conditions like Parkinson’s disease, addiction, and depression. Its high specificity for the dopamine transporter allows for precise experimentation in neuropharmacology and behavioral studies. Additionally, it has been employed in radiolabeling studies to map DAT distribution in the brain, aiding in the development of diagnostic and therapeutic strategies for dopamine-related disorders.