L-168,049 is primarily utilized in research settings as a selective antagonist for the 5-HT2B receptor. Its application is significant in studying the role of this receptor in various physiological and pathological processes. Researchers employ it to investigate cardiovascular functions, as the 5-HT2B receptor is implicated in heart valve regulation and cardiac fibrosis. Additionally, it is used in neuroscience studies to explore the receptor's influence on central nervous system disorders, such as depression and anxiety. By blocking the 5-HT2B receptor, L-168,049 helps elucidate potential therapeutic targets for conditions linked to its overactivation.