LY 344864 S-enantiomer is primarily used in research settings to study its effects on serotonin receptors, particularly the 5-HT1F subtype. It has shown potential in preclinical studies for the treatment of migraines due to its ability to inhibit trigeminal nerve activation, which is associated with migraine pain. Additionally, it is being investigated for its role in neuroprotection and its potential to reduce inflammation in neurological conditions. The S-enantiomer form is specifically studied for its enhanced binding affinity and selectivity, making it a valuable tool in understanding serotonin receptor mechanisms and developing targeted therapies.