LY 344864 is primarily used in research settings to study the role of serotonin receptors, particularly the 5-HT1F subtype, in various physiological processes. It is often employed as a selective agonist to investigate the potential therapeutic effects of targeting these receptors. In neurological research, it has been explored for its potential in treating migraine headaches, as activation of 5-HT1F receptors is believed to inhibit the release of vasoactive peptides involved in migraine pathways. Additionally, LY 344864 is used in preclinical studies to understand its effects on anxiety, depression, and other central nervous system disorders, providing insights into the development of novel pharmacological treatments. Its application is largely confined to experimental and developmental stages, contributing to the advancement of neuroscience and drug discovery.