WAY-659746 is primarily used in scientific research as a potent and selective antagonist for the 5-HT2C receptor, a subtype of serotonin receptor. It serves as a pharmacological tool to investigate the role of 5-HT2C receptors in various physiological and behavioral processes, including mood regulation, appetite control, and reward pathways. Due to its selectivity, it helps researchers differentiate the effects mediated by 5-HT2C from other serotonin receptor subtypes. It has been utilized in preclinical studies to explore potential treatments for psychiatric disorders such as depression, anxiety, and substance use disorders. Additionally, it aids in understanding the mechanisms of drugs that modulate serotonergic signaling. Its application remains confined to laboratory and experimental settings, with no current clinical use in humans.