WAY-638311 is primarily used in neuroscience research as a potent and selective antagonist for the 5-HT6 receptor. Its main application lies in studying the role of serotonin signaling in cognitive functions, memory, and neurodegenerative disorders such as Alzheimer's disease. Due to its high selectivity, it helps researchers dissect the specific contributions of 5-HT6 receptors in behavioral and pharmacological models without significant off-target effects. It has also been employed in preclinical studies to evaluate potential improvements in cognitive performance and to explore novel treatments for psychiatric conditions including schizophrenia and depression. Its use is largely confined to laboratory and experimental settings, supporting the development of new central nervous system therapeutics.