WAY-100635 Maleate is widely used in neuroscience research as a selective serotonin 5-HT1A receptor antagonist. It is commonly employed to block 5-HT1A receptors in experimental models, allowing scientists to study the role of these receptors in mood, anxiety, and depression. It is also used in positron emission tomography (PET) studies as a radioligand to map and quantify 5-HT1A receptor distribution in the brain. This application is particularly valuable in investigating psychiatric and neurological disorders such as major depressive disorder, schizophrenia, and Alzheimer's disease. Due to its high affinity and specificity, it helps validate the involvement of 5-HT1A pathways in drug development and behavioral studies.