WAY-344282 is primarily used in neuroscience research as a potent and selective antagonist for the 5-HT6 (serotonin 6) receptor. Its main application lies in studying cognitive functions, particularly in preclinical models related to Alzheimer’s disease and other cognitive disorders. By blocking 5-HT6 receptors, it helps researchers investigate the role of serotonin signaling in learning, memory, and neuroplasticity. It has also been explored for its potential to enhance the effects of acetylcholinesterase inhibitors, which are commonly used in dementia treatment. Due to its high selectivity and blood-brain barrier permeability, WAY-344282 serves as a valuable tool compound in pharmacological studies aiming to validate 5-HT6 as a therapeutic target for cognitive enhancement and psychiatric conditions.