WAY-622024 is primarily used in research settings as a potent and selective antagonist for the 5-HT6 receptor, making it a valuable tool compound in neuroscience and pharmacology. Its main application lies in studying the role of serotonin signaling in cognitive functions, particularly in models related to Alzheimer’s disease and other neurodegenerative disorders. Researchers use WAY-622024 to investigate improvements in learning and memory, as blockade of the 5-HT6 receptor has been associated with enhanced cholinergic and glutamatergic neurotransmission. It is also employed in preclinical studies to evaluate potential anxiolytic and antidepressant effects, supporting the development of novel central nervous system therapeutics. Due to its high selectivity, it helps isolate receptor-specific effects without significant off-target interactions, improving the accuracy of experimental outcomes.