WAY-327148 is primarily used in scientific research as a selective antagonist for the 5-HT6 receptor, making it a valuable tool in neuroscience and pharmacology studies. It is applied in investigations related to cognitive function, memory, and neurodegenerative disorders such as Alzheimer's disease. Due to its ability to modulate serotonin pathways, it helps researchers understand the role of 5-HT6 receptors in learning and behavior. It has also been explored for its potential in treating psychiatric conditions like schizophrenia and depression, particularly in combination with other cognitive enhancers. Its application remains restricted to preclinical research, mainly in animal models, to evaluate therapeutic strategies targeting serotonergic signaling.