WAY-381644 is primarily used in scientific research as a selective agonist for the 5-HT6 receptor subtype. Its main application lies in neuroscience studies focusing on cognitive function, memory, and neurodegenerative disorders such as Alzheimer's disease. Researchers utilize WAY-381644 to investigate the role of 5-HT6 receptor activation in modulating neurotransmitter systems, particularly acetylcholine and glutamate, which are critical for learning and memory processes. Due to its high selectivity, it serves as a valuable pharmacological tool for validating the therapeutic potential of 5-HT6-targeted compounds in preclinical models. It is not used clinically and remains restricted to laboratory and experimental settings.