PRE-084 hydrochloride is primarily utilized in research settings to study sigma-1 receptor activity. It serves as a selective agonist for sigma-1 receptors, making it valuable for investigating the role of these receptors in cellular processes, particularly in the central nervous system. Researchers use it to explore its potential effects on neuroprotection, cognitive function, and modulation of ion channels. Additionally, it is employed in studies related to psychiatric disorders, neurodegenerative diseases, and pain management, providing insights into the therapeutic potential of sigma-1 receptor modulation. Its application is crucial for advancing understanding of cellular signaling pathways and drug development targeting sigma-1 receptors.