S1RA HCl is primarily used in research settings to study its effects on the sigma-1 receptor, which plays a role in various neurological and psychiatric conditions. It is investigated for its potential therapeutic applications in managing neuropathic pain, depression, and anxiety disorders. Additionally, it is explored for its neuroprotective properties in conditions like Alzheimer's disease and stroke. Researchers also examine its role in modulating cellular stress responses and its potential in cancer therapy due to its impact on cell survival pathways.