NE-100 is primarily used in neuroscience research as a selective sigma-1 receptor antagonist. It is widely employed to study the role of sigma-1 receptors in various neurological and psychiatric disorders. Researchers use NE-100 to investigate its effects on conditions such as depression, anxiety, schizophrenia, and neurodegenerative diseases like Alzheimer's. By blocking sigma-1 receptors, it helps in understanding their involvement in cellular signaling, neuroprotection, and modulation of neurotransmitter systems. Additionally, NE-100 is utilized in preclinical studies to explore potential therapeutic applications and to develop new drugs targeting sigma-1 receptors. Its application extends to behavioral and molecular studies, providing insights into the mechanisms underlying brain function and disease.