Trimethylsilyl isocyanate is widely used in organic synthesis as a reagent for introducing the isocyanate functional group into molecules. It is particularly valuable in the preparation of urethanes, ureas, and other nitrogen-containing compounds. Its reactivity with alcohols and amines makes it a key component in the production of polymers, coatings, and adhesives. Additionally, it is employed in the modification of surfaces and materials to enhance their properties, such as water resistance or adhesion. In pharmaceutical research, it serves as a building block for the synthesis of active pharmaceutical ingredients (APIs) and intermediates. Its ability to act as a protective group for hydroxyl and amino groups during complex chemical reactions further extends its utility in fine chemical manufacturing.