1-[2-(Trimethylsilyl)ethoxycarbonyloxy]benzotriazole (Teoc-OBt) is primarily used in organic synthesis as an activated reagent to introduce the 2-(trimethylsilyl)ethoxycarbonyl (Teoc) protecting group for amines and alcohols. It is particularly effective in peptide and nucleoside synthesis, protecting functional groups selectively during multi-step reactions to ensure orthogonality. The trimethylsilyl-substituted ethyl chain provides chemical stability under various conditions and enables mild deprotection via fluoride (e.g., TBAF) due to the β-silyl effect. This versatility supports its use in preparing sensitive pharmaceutical intermediates, natural products, and fine chemicals, where precise control over protection/deprotection is essential.